Double-blind, placebo controlled trial compared low dose Premarin 0.45mg/d to Transdermal (Climara patch 0.5mcg/d)
Neither affected systolic or diastolic pressure, Premarin increased HDL and TG, decreased LDL
Transdermal improved insulin sensitivity, lowering insulin resistance
No detectable effects on progression of atherosclerosis as assessed by carotid ultrasound and less accumulation of coronary artery calcium
Improved hot flashes, night sweats, mood, sexual function and bone density with HT
No significant difference in breast or endometrial cancer, MI, TIA, stroke or venous thromboembolic disease
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